Globo Medic

The danger of thrombophilia in pregnancy

Thrombosis is a blood disorder that should be treated as soon as possible to avoid repeat miscarriages in pregnant women. Repeated miscarriages are more common than first thought. Up to 15% of pregnant women who experience spontaneous miscarriages throughout pregnancy are at risk of having such a miscarriage again.

This phenomenon is called a recurrent miscarriage. The causes of such abortions can vary, but the main one is known to be thrombotic. The following article will explain thrombophlebitis and how you can treat it.

What is Thrombocytosis?

Thrombotropism is a disorder involving blood clotting. Women suffering from thrombosis can form more blood clots than the body needs, damaging the placenta and causing the pregnant woman to experience spontaneous abortion. In such cases, it is essential to treat this blood problem. Otherwise, women may not become mothers due to repeated abortions.

Thrombophilia is a disorder related to blood coagulation

Thrombocytosis Class

Thrombosis can be hereditary or acquired. In the first case, the disorder is present from birth and is caused by a genetic alteration or a deficiency in a specific protein that usually protects the body from forming blood clots.

The second type of thrombotic tendency is acquired and usually develops during the woman’s lifetime. The origin may be autoimmune or due to a lack of specific proteins.

Risk of thrombosis during pregnancy

Oral contraceptives increase the risk of venous thrombosis and are therefore contraindicated in women with these genetic disorders or whose presence is suspected due to family history.

If a woman wants to take this hormone combination, she needs to undergo a genetic test to determine if she is a carrier of the aforementioned genetic variation. A simple saliva or blood sample is taken to isolate the cell’s DNA and check for genetic mutations. If a woman has these changes in her DNA, she should not take oral contraceptives. This does not happen in everyday life; many women are at risk without knowing it.

Most women with this disorder can have normal pregnancies without complications. These genetic disorders that cause venous thrombosis put affected women at increased risk of miscarriage (pregnancy loss). It may also increase the risk of other complications during pregnancy, such as pre-eclampsia (increased blood pressure), fetal growth restriction, and placental abruption (the placenta separates from the wall of the uterus).

It has also been shown that women have an increased risk of complications during pregnancy if they have antiphospholipid syndrome (also called antiphospholipid syndrome or antiphospholipid antibody syndrome). However, the risk of losing a pregnancy is reduced when low doses of two combination anticoagulants, such as heparin and aspirin (acetylsalicylic acid), are used.

Symptoms of thrombosis

Thrombosis usually has no overt symptoms because it is a risk factor for blood clots and can develop at any time. However, in some cases, it may indicate:

  • Thrombosis
  • Stroke
  • Chest pain when breathing deeply
  • Swelling of the lower extremities
  • Superficial venous circulation
  • Women may have high-risk pregnancies for both the fetus’s and the mother’s health.

Diagnosis of thrombocytosis

Diagnosis of thrombosis is made through a blood test of the pregnant woman. In most cases, such an analysis is performed when a pregnant woman has multiple recurrent miscarriages. As mentioned above, nearly 15% of pregnant women who experience spontaneous abortion tend to have more abortions in their lifetime. This is called a recurrent miscarriage.

Can thrombocytosis be treated?

If a woman tends to become thrombotic, it is essential to initiate appropriate treatment so that the disorder does not lead to repeated miscarriages. For this, treatment based on drugs such as aspirin or heparin must be initiated. Treatment is carried out via subcutaneous injection.

Monitoring thrombocytopenia during pregnancy

As is expected, women with thrombosis will receive stricter follow-ups during pregnancy. Blood tests and ultrasounds are continued to ensure everything goes perfectly and that excessive clotting does not endanger the pregnancy. A haematologist, separate from the gynaecologist, monitors the pregnancy.

Regarding treatment, pregnant women usually present specific bruises at the injection site. Another set of complications is the risk of suffering from a reduced platelet count or intermittent bleeding. Although each case is different and the treatment to be followed varies from person to person, it is essential to discontinue heparin injections one day before epidural anaesthesia. After delivery, you should resume heparin therapy. Otherwise, there is a severe risk that the mother may develop thrombosis. Women with thrombophlebitis are subject to stricter follow-ups during pregnancy.

Monitoring thrombocytopenia during pregnancy


In short, thrombophlebitis is a blood disorder that should be treated as soon as possible to avoid repeat miscarriages in pregnant women. Diagnosis is essential if heparin-based treatment allows women to give birth without problems and prevent the risk of repeated miscarriages. If you do not follow the upper instructions you may face the danger of thrombophilia during pregnancy

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